Ethanol derived acetate modifies brain epigenetic landscape

Derek Sung: @immunofluorescence

Faculty Spotlight: Cesar de la Fuente

Regenerating the lung: harnessing the untapped potential of AT2 cells

Where are they now – Theonie Anastassiadis

Faculty Spotlight: Will Bailis

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March 1, 2018

The human body has over 200 different cell types, and gene regulation is key to establishing and maintaining cell identity. During mitosis, chromatin condenses and long-range interactions between distal enhancers are lost [1]. As a result, scientists have long believed that transcription during mitosis is silenced, raising the question of how cells reactivate transcription to maintain cell identity. How cell identity is controlled is a fundamental biological question, and understanding this process could also provide insights for cell reprogramming and regenerative medicine.

Addressing how cells maintain identity during mitosis is not a trivial issue, give...

May 19, 2017

Clinical microbiology is the application of research for the prevention, direct diagnosis, and treatment of infectious diseases. Clinical microbiology may be a viable career option for those who want to apply their knowledge of infectious disease in clinical settings to promote public health. Two recent CAMB graduates, Jamie Lemon and Alexandra Bryson, pursued this path after leaving Penn. Jamie Lemon was an MVP student in Dr. Jeffrey Weiser’s lab, where she studied the immune response to Streptococcus pneumoniae colonization using a mouse model. She defended her thesis in March 2015 and is currently a second-year Clinical Microbiology Fellow at the NIH....

February 14, 2017

Influenza A viruses, the causative agent of the annual flu, infect birds and some mammals. The viruses are categorized into different subtypes, depending on the types of hemagglutinin (HA) and neuraminidase (NA) proteins located on the surface of the viral envelope. The trivalent flu vaccine contains HA components of the three circulating strains. These viruses undergo significant genetic drift, necessitating an annual update of the flu vaccine. The effectiveness of the vaccine depends on how well the viruses in the vaccine match those in circulation, but antibodies made in response to the vaccine may still provide cross-protection to related viruses.

Dr....

November 7, 2016

As human beings, we all grapple with the soul-searching question of what makes life meaningful. In his memoir When Breath Becomes Air, neurosurgeon Paul Kalanithi endeavors to answer this question as his path towards an illustrious career is tragically cut short by lung cancer. This is a beautifully written, heart-wrenching book that challenges us to reflect on what our core values are and how to live our lives according to those values.

Kalanithi developed a strong appreciation for language as a young man in Arizona. Motivated by the desire to understand what makes life meaningful, he embarked on a scholarly journey of literature and human biology to inte...

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