Ethanol derived acetate modifies brain epigenetic landscape

Derek Sung: @immunofluorescence

Faculty Spotlight: Cesar de la Fuente

Regenerating the lung: harnessing the untapped potential of AT2 cells

Where are they now – Theonie Anastassiadis

Faculty Spotlight: Will Bailis

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May 28, 2018

The ability to target abnormal genes by introducing functional copies through gene therapy holds extreme promise for the treatment of human diseases. Since the first human therapeutic gene transfer in 1990, gene therapies have been efficacious in treating diseases like hemophilia and leukemia, and this list is continuously growing. Importantly, gene therapies reflect a shift in modern medicine from the treatment of symptoms to the permanent correction of underlying genetic causes of disease.

As not all diseases are created equal, gene replacement therapies are harder to implement if the genetic mutations resulting in pathologies are unclear. Recent resear...

November 28, 2017

With its captivating wide-mouthed smile and prominent feathery headdress of gills, it is easy to adore the axolotl (Ambystoma mexicanum). Both salamander enthusiasts and scientists acknowledge the utility of these unique aquatic creatures. Axolotls are wizards of regeneration, a trait that is recognized by biomedical researchers across the globe. A PubMed query for ‘axolotl’ returns more than 3400 results, with recent publications in high impact journals such as Cell and Nature. As axolotls are picking up steam as model organisms, they’re also becoming quite popular in the homes of several CAMB graduate students who share a love for these unique creatures...

August 27, 2017

As a graduate student in the lab of gene therapy pioneer Dr. Dusty Miller at the Fred Hutchison Cancer Research Center, Andy was at the forefront of the fast-paced field of retrovirology. There, he took on multiple projects, first dabbling in AAV-mediated gene therapy, and then honing in on the role of cancer stem cells using a mouse model of a unique Jaagsiekte retroviral-driven lung cancer. Intriguingly, the envelope protein of this retrovirus alone is sufficient to induce pulmonary adenocarcinoma. As his thesis work developed, Andy became more and more interested in cancer stem cells and factors underlying differences in lung cell susceptibility to the...

August 23, 2016

The immune system possesses the essential ability to detect and destroy abnormal cells, such as cancer cells. Recently, the critical interplay between the immune system and cancer has gained much attention, as scientists now recognize that the immune system holds great therapeutic potential for use in the targeted destruction of tumors. However, tumor cells can also exploit certain populations of immune cells to boost their own growth and evade immune system-mediated destruction. Recent research by fifth year Cancer Biology student and Rustgi lab member Tatiana Karakasheva sheds light on the mechanisms underlying this complex contribution of immune cells...

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