Ethanol derived acetate modifies brain epigenetic landscape

Derek Sung: @immunofluorescence

Faculty Spotlight: Cesar de la Fuente

Regenerating the lung: harnessing the untapped potential of AT2 cells

Where are they now – Theonie Anastassiadis

Faculty Spotlight: Will Bailis

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March 1, 2018

Sensorineural hearing loss (SNHL) is a common sensory deficit, which affects 1 in 500 newborns, and can arise from etiologically diverse structural and functional inner ear abnormalities. The mammalian inner ear is an elegant labyrinth that contains a cochlea, the primary auditory organ, and a vestibular system that maintains body balance. Lateral cochlear duct cells, comprising Reissner’s membrane and the stria vascularis, are critical for production, maintenance and secretion of endolymph, a specialized fluid that supports hair cell function. A recent Developmental Cell paper by Alex Rohacek, a DSRB student from Douglas Epstein’s lab, highlights a compl...

March 1, 2018

“Why get up in the morning and fight for grant money and all this? We get to see things that no human has seen before and learn stuff that’s not in any textbook. We get to work with talented students…and watch them grow into scientists!”

This is what excites Dr. Shawn C. Little, PhD., a newly appointed Assistant Professor in the Department of Cell and Developmental Biology at the Perelman School of Medicine.

Shawn is no stranger to Penn. He completed his doctoral thesis with Dr. Mary C. Mullins in 2008,on the role of transforming growth factor beta signaling in early zebrafish development. His work elucidated how bone morphogenetic protein gradients conferr...

August 27, 2017

As a graduate student in the lab of gene therapy pioneer Dr. Dusty Miller at the Fred Hutchison Cancer Research Center, Andy was at the forefront of the fast-paced field of retrovirology. There, he took on multiple projects, first dabbling in AAV-mediated gene therapy, and then honing in on the role of cancer stem cells using a mouse model of a unique Jaagsiekte retroviral-driven lung cancer. Intriguingly, the envelope protein of this retrovirus alone is sufficient to induce pulmonary adenocarcinoma. As his thesis work developed, Andy became more and more interested in cancer stem cells and factors underlying differences in lung cell susceptibility to the...

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