Regenerating the lung: harnessing the untapped potential of AT2 cells

Where are they now – Theonie Anastassiadis

Faculty Spotlight: Will Bailis

Be The Match

GRAthletes in CAMB: Coral Kasden competes at 2019 Pan American Games in Lima, Peru

Greening Our Labs

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August 25, 2018

Stemming from a relatively recent explosion of research, the epigenetic regulation of gene expression is now appreciated as an important biological phenomenon. The prefix “epi-” means above or around in Greek, as epigenetics is defined by the study of DNA modifications that do not change the underlying sequence of the DNA. Importantly, these additions change cellular gene expression to diversify the functionality of cells with the same underlying genetic code.

Chemical modifications to DNA such as methyl groups (mCpG) are dynamically regulated to govern cell fate during development. The family of DNA methyltransferase enzymes, or DNMTs, covalently add mCp...

April 26, 2016

The Cell and Molecular Biology (CAMB) program spans a daunting breadth of biological inquiry, with students and investigators participating across six dynamic and complementary programs. This diversity is exemplified by the research of Ellen Elliott, recent alumna of the Developmental, Stem Cell and Regenerative Biology (DSRB) program and the Kaestner laboratory. Her work integrates the methods and concepts of regenerative biology, organismal development, physiology, and epigenetic regulation to investigate the role of DNA methylation in mammalian intestinal epithelia. In the January 2016 issue of eLife, Ellen and colleagues present that the DNA methyltra...

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