Ethanol derived acetate modifies brain epigenetic landscape

Derek Sung: @immunofluorescence

Faculty Spotlight: Cesar de la Fuente

Regenerating the lung: harnessing the untapped potential of AT2 cells

Where are they now – Theonie Anastassiadis

Faculty Spotlight: Will Bailis

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February 8, 2020

The physiological effects of alcohol on the brain and motor function have been studied extensively for decades. In low doses, alcohol causes euphoria and reduces anxiety, while in higher doses it impairs cognition and balance, and increases response time. Long-term consumption of alcohol is associated with changes in memory and alcohol-related learning, which play important roles in the development of alcohol use disorder. Dr. Philipp Mews, a CAMB graduate from the Genetics and Gene Regulation (now Genetics and Epigenetics) sub-program, explored the link between alcohol metabolism, gene expression, and alcohol-related learning behaviors, and recently publ...

August 27, 2017

Hippocampal memory formation requires neuroplasticity, which is produced by the orchestrated expression of neuronal genes through chromatin modification1,2. Histone acetylation is a post-translational modification of histone proteins that helps to restructure chromatin and regulate the ability to store and recall previously acquired information3. Histone acetyltransferases (HATs) transfer acetyl groups (-COCH3) to the lysine residues of histone tails, thus neutralizing the positive charges and decreasing their affinity for negatively charged DNA that is wound around the nucleosome. This process allows the condensed chromatin structure to relax and local g...

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