Regenerating the lung: harnessing the untapped potential of AT2 cells

Where are they now – Theonie Anastassiadis

Faculty Spotlight: Will Bailis

Be The Match

GRAthletes in CAMB: Coral Kasden competes at 2019 Pan American Games in Lima, Peru

Greening Our Labs

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August 27, 2017

Hippocampal memory formation requires neuroplasticity, which is produced by the orchestrated expression of neuronal genes through chromatin modification1,2. Histone acetylation is a post-translational modification of histone proteins that helps to restructure chromatin and regulate the ability to store and recall previously acquired information3. Histone acetyltransferases (HATs) transfer acetyl groups (-COCH3) to the lysine residues of histone tails, thus neutralizing the positive charges and decreasing their affinity for negatively charged DNA that is wound around the nucleosome. This process allows the condensed chromatin structure to relax and local g...

May 20, 2017

Transcription factors mediate many essential processes. The role of transcription factors in mediating neuronal growth, function, and regeneration is not well known. It is particularly poorly understood how the development, branching, and regrowth of motor neurons are regulated. There is also little known about how transcription factors regulate dendrite (projections of neurons) and how this works in conjunction with axonal outgrowth and targeting.

Regulation of dendrite and axon positioning is necessary to define a neuron’s connections and is controlled by a combination of guidance receptors, adhesion molecules, and cytoskeletal regulators. The lab of Dr....

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