Ethanol derived acetate modifies brain epigenetic landscape

Derek Sung: @immunofluorescence

Faculty Spotlight: Cesar de la Fuente

Regenerating the lung: harnessing the untapped potential of AT2 cells

Where are they now – Theonie Anastassiadis

Faculty Spotlight: Will Bailis

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November 27, 2018

When we consider the future of cancer treatment, chemotherapy pales in comparison to immunotherapy. Unlike chemotherapy, which stops or blocks rapidly growing cells and can lead to adverse side effects, immunotherapy modifies a patient’s own cells to enhance or restore the cancer-fighting ability of the immune system. Immunotherapy has led to a marked improvement in clinical outcomes, but unfortunately only a subset of patients respond positively to this treatment. It is well known that different tumors have diverse genetic and epigenetic alterations that contribute to the range of phenotypes, and ultimately the success of treatment. However, the field la...

November 28, 2017

Cancer research has seen a steady shift towards ‘tumor microenvironment’ driven hypotheses. Tumor cells exploit their environment to fuel their own growth and metastases. Thus, targeting the crosstalk between the tumor cells, stromal cells and the immune microenvironment has gained new appreciation for cancer therapeutics. 

Paracrine or juxtacrine signaling via soluble chemokines and cytokines are the major known drivers of the crosstalk between the heterotypic cells in a tumor. However, the role of exosomes (extracellular vesicles) as dynamic modulators of intercellular communication has only recently been highlighted. A study published in Cell in July 20...

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